Keywords
polysaccharides
hypoglycemic effect
diabetes mellitus
streptozotocin
How to Cite
Abstract
Diabetes mellitus can result in hyperglycemia caused by insufficient insulin secretion or insulin resistance. As such, plant extracts that exert a hypoglycemic effect with limited side effects are of interest to the medical and healthcare fields. The hypoglycemic effect of polysaccharides extracted from the branches of Actinidia arguta was explored in mice in this study. Sixty male Kunming mice were subsequently randomly assigned to one of six groups. The body weight, fasting blood glucose level, serum lipids, and oxidative stress parameters were assessed weekly during the 28-day study period. Pancreatic tissue from sacrificed mice was harvested at the end of the study and dissected for analysis. Polysaccharide AABP3 prevented body weight loss and decreased the fasting blood glucose level in diabetic mice compared with control mice. It also had a beneficial effect on serum dyslipidemia and oxidative stress parameters and was comparable in its protective effect to metformin. Histopathological examination of the pancreas revealed that AABP3 could protect and ameliorate pancreatic damage that may occur in diabetes mellitus in mice. AABP3 may be considered a potential candidate for developing a functional food or natural product for treating diabetes and its complications.
References
Adefegha, S.A., Oboh, G., Adefegha, O.M., Boligon, A.A., & Athayde, M.L. (2014). Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove (Szyzgium aromaticum) bud powder in a high-fat diet/streptozotocin-induced diabetes rat model. Journal of the Science of Food and Agriculture, 94(13), 2726–2737. https://doi.org/10.1002/jsfa.6617
Akindele, A.J., Otuguor, E., Singh, D., Ota, D., & Benebo, A.S. (2015). Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats. European Journal of Pharmacology, 762, 174–183. https://doi.org/10.1016/j.ejphar.2015.05.044
Cao, H. (2013). Polysaccharides from Chinese tea: recent advance on bioactivity and function. International Journal of Biological Macromolecules, 62(11), 76–79. https://doi.org/10.1016/j.ijbiomac.2013.08.033
Chen, G., Yuan, Q., Saeeduddin, M., Ou, S., Zeng, X., & Ye, H. (2016). Recent advances in tea polysaccharides: extraction, purification, physicochemical characterization and bioactivities. Carbohydrate Polymers, 153, 663–678. https://doi.org/10.1016/j.carbpol.2016.08.022
Chen, X., Qian, L., Wang, B., Zhang, Z., Liu, H., Zhang, Y., & Liu J. (2019). Synergistic hypoglycemic effects of pumpkin polysaccharides and puerarin on type II diabetes mellitus mice. Molecules, 24(5), Article 955. https://doi.org/10.3390/molecules24050955
Drucker, D.J., & Nauck, M.A. (2006). The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. The Lancet, 368(9548), 1696–1705. https://doi.org/10.1016/S0140-6736(06)69705-5
Emordi, J.E., Agbaje, E.O., Oreagba, I.A., & Iribhogbe, O.I. (2016). Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats. BMC Complementary and Alternative Medicine, 16, Article 468. https://doi.org/10.1186/s12906-016-1450-0
Fu, J., Fu, J., Liu, Y., Li, R., Gao, B., Zhang, B., Wang, B., Cao, Y., Guo, K., & Tu, Y. (2012). Modulatory effects of one polysaccharide from Acanthopanax senticosus in alloxan-induced diabetic mice. Carbohydrate Polymers, 87(3), 2327–2331. https://doi.org/10.1016/j.carbpol.2011.10.068
Kahn, S.E., Hull, R.L., & Utzschneider, K.M. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 444(7121), 840–846. https://doi.org/10.1038/nature05482
Li, Y., Cui, W., Wang, R., Lin, M., Zhong, Y., Sun, L., Qi, X., & Fang, J. (2019). MicroRNA858-mediated regulation of anthocyanin biosynthesis in kiwifruit (Actinidia arguta) based on small RNA sequencing. PloS ONE, 14(5): Article e0217480. https://doi.org/10.1371/journal.pone.0217480
Liu, W., Lu, W., Chai, Y., Liu, Y., Yao, W., & Gao, X. (2017). Preliminary structural characterization and hypoglycemic effects of an acidic polysaccharide SERP1 from the residue of Sarcandra glabra. Carbohydrate Polymers, 176, 140–151. https://doi.org/10.1016/j.carbpol.2017.08.071
Liu, W., Zheng, Y., Zhang, Z., Yao, W., & Gao, X. (2014). Hypoglycemic, hypolipidemic and antioxidant effects of Sarcandra glabra polysaccharide in type 2 diabetic mice. Food & Function, 5, 2850–2860. https://doi.org/10.1039/C4FO00430B
Pan, L.H., Li, X.F., Wang, M.N., Zha, X.Q., Yang, X.F., Liu, Z.J., Luo, Y.B., & Luo, J.P. (2014). Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species. International Journal of Biological Macromolecules, 64, 420–427. https://doi.org/10.1016/j.ijbiomac.2013.12.024
Rangika, B.S., Dayananda, P.D., & Peiris, D.C. (2015). Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice. BMC Complementary and Alternative Medicine, 15, Article 289. https://doi.org/10.1186/s12906-015-0807-0
Ridderstrale, M., & Groop, L. (2009). Genetic dissection of type 2 diabetes. Molecular and Cellular Endocrinology, 297(1–2), 10–17. https://doi.org/10.1016/j.mce.2008.10.002
Shin, H., Park, Y, Song, J.H., Kim M.S., Kim, J.H., Kim, S.H., Ahn, J.H., & Lu, M.K. (2019). Analysis of bioactive constituents of Hardy Kiwi (Actinidia arguta). Planta Medica, 85(18), 1509. https://doi.org/10.1055/s-0039-3399949
Skrypchenko, N. (2017). Actinidia in Ukraine. Ruta. (In Ukrainian)
Stumvoll, M., Goldstein, B.J., & van Haeften, T.W. (2005). Type 2 diabetes: principles of pathogenesis and therapy. The Lancet, 365(9467), 1333–1346. https://doi.org/10.1016/S0140-6736(05)61032-X
Wang, S., Lu, A., Zhang, L., Shen, M., Xu, T., Zhan, W., Jin, H., Zhang, Y., & Wang, W. (2017). Extraction and purification of pumpkin polysaccharides and their hypoglycemic effect. International Journal of Biological Macromolecules, 98, 182–187. https://doi.org/10.1016/j.ijbiomac.2017.01.114
Xu, P., Wu, J., Zhang, Y., Chen, H., & Wang, Y.F. (2014). Physicochemical characterization of puerh tea polysaccharides and their antioxidant and alpha-glycosidase inhibition. Journal of Functional Foods, 6, 545–546. https://doi.org/10.1016/j.jff.2013.11.021
Ye, H., Shen, Z., Cui, J., Zhu, Y., Li, Y., Chi, Y., Wang, J., & Wang, P. (2019). Hypoglycemic activity and mechanism of the sulfated rhamnose polysaccharides chromium (III) complex in type 2 diabetic mice. Bioorganic Chemistry, 88, Article 102942. https://doi.org/10.1016/j.bioorg.2019.102942
Zhang, J., An, S., Hu, W., Teng, V., Wang, X., Qu, Y., Liu, Y., Yuan, Y., & Wang, D. (2016). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer’s disease mouse model. International Journal of Molecular Sciences, 17(11), Article 1810. https://doi.org/10.3390/ijms17111810
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